Journal of Agricultural and Food Chemistry · 2018 · 47 citations · 19 references
PharmacyPharmaceuticsToxicologyDrug DeliveryNanomaterialsNanoparticle Drug DeliveryDrug EncapsulationNanomaterials For Drug DeliveryNanoparticle CharacterizationNanoparticle Delivery SystemsNanoparticle FormulationsNanoparticle StabilityDrug Delivery NanocarriersEncapsulationNanocarrier StabilityNanoparticle DeliveryNanoparticle-based Controlled ReleaseNanoparticlesPolymeric NanocarriersSuspensions
Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of λ-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEG-PDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.
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Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin
Zhiyu He, José Luís Santos, Houkuan Tian et al. · Biomaterials · 2017 · 243 citations