Small molecules bind human mTOR protein and inhibit mTORC1 specifically

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

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The coordinate regulation of the p53 and mTOR pathways in cells

Zhaohui Feng, Haiyan Zhang, Arnold J. Levine · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

Xiaolin Wan, B Harkavy, Patrick J. Grohar et al. · Oncogene · 2006 · 747 citations

Life Sciences, Biochemistry, Molecular Biology +12

The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

H Nojima, Chiharu Tokunaga, Satoshi Eguchi et al. · Journal of Biological Chemistry · 2003 · 681 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13