Concepedia

Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging

Jung Eun Lee, Myung Goo Kim, Yeon Lim Jang, Min Sang Lee, Nak Won Kim, Yue Yin, Jong Han Lee, Su Yeon Lim, Ji Won Park, Jaeyun Kim,

Drug Delivery · 2018 · 43 citations · 22 references

DOIFull text

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Abstract

. When systemically administered in a mouse xenograft model for human breast cancer, the HSA-PEG-based nanoparticle formulation exhibited an extended systemic circulation for more than 96 h and enhanced intratumoral accumulation, resulting in a remarkable anticancer effect and prolonged survival of the animals.

References

22

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

, , +12

Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

Stephen Curry, Hendrik Mandelkow, P. Brick · Nature Structural Biology · 1998 · 1.4K citations

, , +13

Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

Neil Desai, Vuong Trieu, Zhiwen Yao et al. · Clinical Cancer Research · 2006 · 1.2K citations

, , +14

Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel.

Nuhad K. Ibrahim, Neil Desai, Sewa S. Legha et al. · PubMed · 2002 · 630 citations

, , +16

Desolvation process and surface characterisation of protein nanoparticles

Carolin Weber, Conrad Coester, J. Kreuter et al. · International Journal of Pharmaceutics · 2000 · 600 citations

, , +16