Concepedia

Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells

Silvia Mele, Stephen Devereux, Andrea Pepper, Elvira Infante, Anne J. Ridley

Blood Advances · 2018 · 41 citations · 50 references

DOIFull text

Open access

Concepts

Abstract

Key Points Basal intracellular Ca2+ levels and migration increase with higher CD38 expression in CLL cells. Rap1 and the Rap1 guanine-nucleotide exchange factor RasGRP2 are required for CLL migration and regulated by CD38 levels.

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