Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity

Increasing the precision of comparative models with YASARA NOVA—a self‐parameterizing force field

Elmar Krieger, Günther Koraimann, Gert Vriend · Proteins Structure Function and Bioinformatics · 2002 · 1.5K citations · Full text

Life Sciences, Bioinformatics, Biophysics +17

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

Theodore W. C. Lo, Marie Westwood, Antony C. McLellan et al. · Journal of Biological Chemistry · 1994 · 695 citations · Full text

Life Sciences, Biochemistry, Enzymology +11

N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins

S. Jayarama Reddy, Kevin J. Wells‐Knecht, Suzanne R. Thorpe et al. · Biochemistry · 1995 · 519 citations

Life Sciences, Biochemistry, Immunology +8

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Alessandra K. Cardozo, Fernanda Ortis, Joachim Størling et al. · Diabetes · 2005 · 518 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Masahiro Shinohara, Paul J. Thornalley, Ida Giardino et al. · Journal of Clinical Investigation · 1998 · 515 citations · Full text

Life Sciences, Biochemistry, Cell Biology +8