Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise, +13

Nature Methods

BiologyBiological-image AnalysisImage AnalysisEngineeringMicroscope Image Processing +6

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Ash A. Alizadeh, Michael B. Eisen, R. Eric Davis, +28

Nature

Hematological MalignancyLymphoid NeoplasiaImmunologyDistinct TypesPathology +6

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

Jürgen Cox, Nadin Neuhauser, Annette Michalski, +3

Journal of Proteome Research

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem, Neville E. Sanjana, Ella Hartenian, +8

Science

EngineeringGeneticsGecko LibraryTumor BiologyHuman Cells +14

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender, +10

Nature Biotechnology

Systems BiologyOff-target EffectNatural SciencesMolecular BiologySgrna Design +8

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Yasemin Sancak, Liron Bar‐Peled, Roberto Zoncu, +3

Cell

Protein FunctionMolecular PhysiologySignal TransductionBiochemistryAmino Acids +12

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

Roland Schmitz, George W. Wright, Da Wei Huang, +37

New England Journal of Medicine

Identification and characterization of essential genes in the human genome

Kıvanç Birsoy, Nicholas W. Hughes, Kevin M. Krupczak, +4

Science

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Traver Hart, Megha Chandrashekhar, Michael Aregger, +15

Cell

Genotype-specific Cancer LiabilitiesEngineeringGeneticsGenetic EngineeringMolecular Genetics +7

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

R. Eric Davis, Vu N. Ngo, Georg Lenz, +34

Nature

Lymphoid NeoplasiaImmunologyPathologyAdult T-cell Leukemia-lymphomaMedicine +2