Concepedia

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy

Chor Ho Jo, Sua Kim, Joon-Sung Park, Gheun‐Ho Kim

Kidney & Blood Pressure Research · 2018 · 55 citations · 40 references

DOIFull text

Open access

Abstract

NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.

References

40

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

Allison A. Eddy, Cecilia M. Giachelli, with the technical assistance of Lorinda McCulloch et al. · Kidney International · 1995 · 365 citations

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Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

Keizo Kanasaki, Sen Shi, Megumi Kanasaki et al. · Diabetes · 2014 · 360 citations · Full text

Salt Induces Myocardial and Renal Fibrosis in Normotensive and Hypertensive Rats

Henry Yu, Louise M. Burrell, M. Jane Black et al. · Circulation · 1998 · 345 citations · Full text

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

Mika Nabeno, Fumihiko Akahoshi, Hiroyuki Kishida et al. · Biochemical and Biophysical Research Communications · 2013 · 297 citations

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