Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

Keizo Kanasaki, Sen Shi, Megumi Kanasaki, +7

Diabetes

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition

Sen Shi, Swayam Prakash Srivastava, Megumi Kanasaki, +7

Kidney International

AngiogenesisSignal TransductionEndothelial DysfunctionCell-matrix InteractionEpithelial-mesenchymal Interactions +6

Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial–Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis

Fan Yang, Yuta Takagaki, Yasuo Yoshitomi, +8

Cancer Research

A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, +5

Diabetologia

ObesityMetabolic SyndromeMtorc1 PathwayCell AutophagyAutophagy Induction +13

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition

Takako Nagai, Megumi Kanasaki, Swayam Prakash Srivastava, +6

BioMed Research International

Microrna Let-7 ExpressionEndothelial-mesenchymal TransitionImmunologyInflammationFibroblast Growth Factor +20

FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway

Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, +6

Cell Death and Disease

Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis

Swayam Prakash Srivastava, Sen Shi, Megumi Kanasaki, +7

Scientific Reports

Knockdown of LncRNA-H19 Ameliorates Kidney Fibrosis in Diabetic Mice by Suppressing miR-29a-Mediated EndMT

Sen Shi, Li Song, Hao Yu, +4

Frontiers in Pharmacology

Linagliptin but not Sitagliptin inhibited transforming growth factor-β2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition

Sen Shi, Keizo Kanasaki, Daisuke Koya

Biochemical and Biophysical Research Communications

Endothelial-mesenchymal TransitionImmunologyInflammationMolecular PharmacologyAngiogenesis +14

Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen

Kyoko Nitta, Sen Shi, Takako Nagai, +6

BioMed Research International

Renal PathologyDiabetic MiceRenal InflammationInflammationGlomerulonephritis +19