Design, synthesis and anticancer evaluation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

I. Vermes, C. Haanen, H M Steffens-Nakken et al. · Journal of Immunological Methods · 1995 · 5.4K citations · Full text

Life Sciences, Cell Biology, Pathology +13

<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram et al. · New England Journal of Medicine · 2005 · 3.9K citations · Full text

Medicine, Oncology, Pharmacology +15

Cell Sensitivity Assays: The MTT Assay

Johan van Meerloo, Gertjan J.L. Kaspers, Jacqueline Cloos · Methods in molecular biology · 2011 · 2.5K citations

Dentistry, Cell Biology, Cell Therapy +9

Rational design of inhibitors that bind to inactive kinase conformations

Yi Liu, Nathanael S. Gray · Nature Chemical Biology · 2006 · 1.1K citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14