<i>Lactobacillus fermentum</i> Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

Abstract

LC40 treatment prevents hypertension and endothelial dysfunction induced by tacrolimus by inhibiting gut dysbiosis. These effects are associated with a reduction in vascular oxidative stress, mainly through NOX2 downregulation and prevention of eNOS uncoupling, and inflammation possibly because of decreased Th17 and increased Treg cells polarization in mesenteric lymph nodes.