Saudi Journal of Biological Sciences · 2018 · 41 citations · 11 references
MedicineGeneticsOncologyCancer GeneticsMolecular OncologyTumor ProgressionCancer Cell SignalingColorectal CancerGenetic Risk AssessmentOncogenic Signaling PathwaysSignal Transduction In CancerWnt SignalingCanonical Beta-catenin SignalingCanonical Wnt PathwayCanonical Wnt SignalingGenetic Risk VariantsProtective Genetic VariantsSingle-nucleotide PolymorphismsWnt In CancerWnt Signal Transduction
The Wnt/β-catenin signaling pathway has been etiologically implicated in the development and progression of colorectal cancer. We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). Evaluation of WNT pathway SNPs showed protective association for rs4135385, located in β-catenin. Additionally, variants in SFRP3 (rs7775) and LRP6 (rs2284396) which did not show any association in the overall analysis were significantly associated with female and old aged colorectal cancer patients, respectively.
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Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
Roel Nusse, Albert van Ooyen, David Cox et al. · Nature · 1984 · 613 citations