Macrocyclic peptides as regulators of protein-protein interactions

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Christian E. Schafmeister, Julia Po, Gregory L. Verdine · Journal of the American Chemical Society · 2000 · 1K citations

Life Sciences, Biochemistry, Metabolic Stability +13

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 661 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in <i>Pseudomonas aeruginosa</i>

Nityakalyani Srinivas, Peter Jetter, Bernhard J. Ueberbacher et al. · Science · 2010 · 551 citations

Life Sciences, Microbiology, Pharmacology +17

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R. White, Chad M. Renzelman, Arthur C Rand et al. · Nature Chemical Biology · 2011 · 384 citations

Pharmacy, Medicinal Chemistry, Drug Delivery +10

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

Steven A. Kawamoto, Adriana Coleska, Ran Xu et al. · Journal of Medicinal Chemistry · 2011 · 245 citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +15