miR‑205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer cells

Abstract

MicroRNA‑205 (miR‑205) has been reported to be downregulated, and serves critical roles in the pathogenesis and progression of several types of cancer, including breast, prostate and lung cancer. However, the underlying mechanism of miR‑205 in thyroid cancer remains unclear. In the present study, it was demonstrated that the expression of miR‑205 was reduced in thyroid cancer tissues compared with non‑cancer tissues. In addition, miR‑205‑knockdown models in the BHT‑101 cell line and ectopic expression models in the 8505‑C cell line were used to measure the biological functions of miR‑205. The results indicated that miR‑205 inhibited certain aspects of thyroid cancer, including cell proliferation, migration and invasion. Furthermore, Yes‑associated protein 1 (YAP1) was identified as a target gene of miR‑205 and its expression was negatively correlated with that of miR‑205 in thyroid cancer tissues. Depletion of YAP1 partially reduced the anti‑miR‑205‑induced cell growth and invasion. The results of the present study suggested that the tumor suppressive functions of miR‑205 via targeting YAP1 could be a novel target for the treatment of thyroid cancer.