Trans‐cinnamic aldehyde inhibits <i>Aggregatibacter actinomycetemcomitans</i>‐induced inflammation in THP‐1–derived macrophages via autophagy activation

Abstract

Trans-cinnamic aldehyde inhibited Aa-stimulated expression of inflammatory responses and inhibited intracellular bacterial survival via autophagy activation. These results suggest that trans-cinnamic aldehyde may serve as an anti-inflammatory agent for aggressive periodontitis.