Concepedia

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

Erietta Stelekati, Zeyu Chen, Sasikanth Manne, Makoto Kurachi, Mohammed-Alkhatim Ali, Keith Lewy, Zhangying Cai, Kito Nzingha, Laura M. McLane, Jennifer L. Hope,

Cell Reports · 2018 · 102 citations · 48 references

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Abstract

During persistent viral infections, exhausted T cells (T EX ) erode quantitatively and qualitatively and therefore fail to provide protection. Stelekati et al. identified microRNA (miR)-155 as a key molecule that can enhance and sustain T EX responses long-term during chronic viral infection.

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