Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bertram Bengsch, Andrew L. Johnson, Makoto Kurachi, +8

Immunity

Metabolic AlterationsBioenergetic Insufficiencies DueSignal TransductionMedicineT-regulatory Cell +13

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

Zeyu Chen, Zhicheng Ji, Shin Foong Ngiow, +24

Immunity

Transcriptional RegulationSignal TransductionT-regulatory CellImmunologyCellular Regulatory Mechanism +7

Characterization of T-Bet and Eomes in Peripheral Human Immune Cells

James J. Knox, Gabriela L. Cosma, Michael R. Betts, +1

Frontiers in Immunology

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyImmune Regulation +21

Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations

Laura M. McLane, Pinaki P. Banerjee, Gabriela L. Cosma, +4

The Journal of Immunology

ChromatinTranscriptional RegulationImmunological MemorySignal TransductionDevelopmental Biology +13

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

Laura M. McLane, Shin Foong Ngiow, Zeyu Chen, +15

Cell Reports

Expanding the Definition of the Classical Bipartite Nuclear Localization Signal

Allison Lange, Laura M. McLane, Ryan E. Mills, +2

Traffic

Nuclear ImportNuclear PhysicsSignal RecognitionMolecular BiologyIntegrase Cnls +14

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

Erietta Stelekati, Zeyu Chen, Sasikanth Manne, +10

Cell Reports

A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by limiting the pools of Dcp2-accessible targets for cap-snatching

Kaycie C. Hopkins, Laura M. McLane, Tariq Maqbool, +3

Genes & Development

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function

Makoto Kurachi, Junko Kurachi, Zeyu Chen, +9

Nature Protocols

Mouse T CellsRetroviral TransductionAdaptive Immune SystemT-regulatory CellImmunology +9

The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus

Laura M. McLane, Kanika F. Pulliam, Scott E. Devine, +1

Nucleic Acids Research

ChromatinSystems BiologyNatural SciencesHuman RetrovirusMolecular Biology +12