Depleting Macrophages In Vivo with Clodronate-Liposomes

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

Andrew Chow, Daniel Lucas, Andrés Hidalgo et al. · The Journal of Experimental Medicine · 2011 · 829 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Retro-orbital injections in mice

Tal Yardeni, Michael Eckhaus, H Douglas Morris et al. · Lab Animal · 2011 · 541 citations

Veterinary Medicine, Pharmacology, Drug Delivery +1

Clodronate and Liposome-Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′-(β,γ-Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro

Julie C. Frith, Jukka Mönkkönen, G. Michael Blackburn et al. · Journal of Bone and Mineral Research · 1997 · 440 citations · Full text

Medicine, Pharmacology, Toxicology +12

Liposomes for Specific Depletion of Macrophages from Organs and Tissues

Nico van Rooijen, Esther M. L. Hendrikx · Methods in molecular biology · 2009 · 377 citations

Life Sciences, Cell Biology, Immunology +11

Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite

Petri Lehenkari, Maarit Kellinsalmi, Juha Näpänkangas et al. · Molecular Pharmacology · 2002 · 328 citations

Medicine, Cell Biology, Pharmacology +17