Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite

The mitochondrial permeability transition pore and its role in cell death

Martin Crompton · Biochemical Journal · 1999 · 2.3K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

D. E. Hughes, Kenneth R. Wright, Harry L. Uy et al. · Journal of Bone and Mineral Research · 1995 · 1K citations

Medicine, Cell Biology, Pharmacology +17

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

Masahiko Sato, W A Grasser, Naoto Endo et al. · Journal of Clinical Investigation · 1991 · 1K citations · Full text

Medicine, Endocrinology, Bone Augmentation +14

Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

James E. Dunford, Keith Thompson, Fraser P. Coxon et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 896 citations

Medicine, Medicinal Chemistry, Pharmacology +17