Julie C. Frith

Cellular and molecular mechanisms of action of bisphosphonates

Michael J. Rogers, Sharon Gordon, Helena L. Benford et al. · Cancer · 2000 · 712 citations · Full text

Medicine, Cell Biology, Molecular Biology +12

Clodronate and Liposome-Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′-(β,γ-Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro

Julie C. Frith, Jukka Mönkkönen, G. Michael Blackburn et al. · Journal of Bone and Mineral Research · 1997 · 440 citations · Full text

Medicine, Pharmacology, Toxicology +12

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis

Julie C. Frith, Jukka M�nkk�nen, Seppo Auriola et al. · Arthritis & Rheumatism · 2001 · 267 citations

Medicine, Cell Biology, Pharmacology +17

Farnesol and Geranylgeraniol Prevent Activation of Caspases by Aminobisphosphonates: Biochemical Evidence for Two Distinct Pharmacological Classes of Bisphosphonate Drugs

Helena L. Benford, Julie C. Frith, Seppo Auriola et al. · Molecular Pharmacology · 1999 · 257 citations

Life Sciences, Biochemistry, Pharmacology +9

The Ability of Statins to Inhibit Bone Resorption Is Directly Related to Their Inhibitory Effect on HMG-CoA Reductase Activity

Ada Staal, Julie C. Frith, M. H. French et al. · Journal of Bone and Mineral Research · 2003 · 174 citations

Medicine, Biochemistry, Pharmacology +17