Concepedia

The BET bromodomain inhibitor apabetalone induces apoptosis of latent HIV-1 reservoir cells following viral reactivation

Xuanxuan Zhang, Jian Lin, Taizhen Liang, Heng Duan, Xing-hua Tan, Baomin Xi, Lin Li, Shuwen Liu

Acta Pharmacologica Sinica · 2018 · 26 citations · 39 references

DOI

Concepts

References

39

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Diana Finzi, Joel N. Blankson, Janet D. Siliciano et al. · Nature Medicine · 1999 · 2.1K citations

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Tae‐Wook Chun, Lieven Stuyver, Stephanie B. Mizell et al. · Proceedings of the National Academy of Sciences · 1997 · 2K citations

, , +16

Decay characteristics of HIV-1-infected compartments during combination therapy

Alan S. Perelson, Paulina Essunger, Yunzhen Cao et al. · Nature · 1997 · 1.9K citations

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

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