Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin

The antioxidant function of the p53 tumor suppressor

Anna Sablina, Andrei V. Budanov, G. V. Ilyinskaya et al. · Nature Medicine · 2005 · 1.1K citations · Full text

Antioxidant Function, Cell Death, Tumor Suppressor +4

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Aaron A. Goodarzi, Angela T. Noon, Dorothee Deckbar et al. · Molecular Cell · 2008 · 822 citations · Full text

Chromatin, Genome Instability, Dna Damage +11

Randomized Phase III Trial of Gemcitabine Plus Cisplatin Compared With Gemcitabine Alone in Advanced Pancreatic Cancer

Volker Heinemann, D. Quietzsch, Frank Gieseler et al. · Journal of Clinical Oncology · 2006 · 682 citations

p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

Hans Christian Reinhardt, Aaron Aslanian, Jacqueline A. Lees et al. · Cancer Cell · 2007 · 592 citations · Full text

P53-deficient Cells Rely, Genome Instability, P38mapk/mk2 Pathway +8

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

Evguenia M. Alexandrova, Alisha R. Yallowitz, Dun Li et al. · Nature · 2015 · 360 citations · Full text

Tumor Biology, Medicine, Stabilized Mutant P53 +9