Nature · 2015 · 366 citations · 26 references
MedicineCancer BiologyOncologyCancer GeneticsCarcinogenesisMolecular OncologyCancer ImmunotherapyDna Damage-induced ApoptosisMalignant NeoplasmsPersonalized Cancer TherapyTargeted Cancer TherapyTargeted TherapyP53 InactivationP53 MutationP53 Pathway InactivationTp53 MutationsTumor Suppressor P53
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina, Giordano Caponigro, Nicolas Stransky et al. · Nature · 2012 · 8.5K citations
Medicine, Oncology, Pharmacology +15
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
Tumor spectrum analysis in p53-mutant mice
Tyler Jacks, Lee Ann Remington, Bart O. Williams et al. · Current Biology · 1994 · 2.1K citations
Medicine, Cancer Biology, Oncology +12
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin et al. · Nature · 2007 · 1.8K citations
Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome
Kenneth P. Olive, David A. Tuveson, Zachary C. Ruhe et al. · Cell · 2004 · 1.3K citations · Full text