Concepedia

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

Chia‐Ju Hsieh, Kuiying Xu, Iljung Lee, Thomas J. A. Graham, Zhude Tu, Dhruva D. Dhavale, Paul T. Kotzbauer, Robert H. Mach

ACS Omega · 2018 · 41 citations · 23 references

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Concepts

Abstract

is a secondary lead compound for structure-activity relationship studies aimed at identifying a suitable compound for positron emission tomography-imaging studies of insoluble Asyn aggregates in Parkinson's disease.

References

23

VMD: Visual molecular dynamics

William Humphrey, Andrew Dalke, Klaus Schulten · Journal of Molecular Graphics · 1996 · 66.6K citations

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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

Andrew Hughes, S. E. Daniel, Linda Kilford et al. · Journal of Neurology Neurosurgery & Psychiatry · 1992 · 10.4K citations · Full text

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What features improve the accuracy of clinical diagnosis in Parkinson's disease

Andrew Hughes, Yoav Ben‐Shlomo, Susan E. Daniel et al. · Neurology · 1992 · 1.3K citations

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Synthesis and Evaluation of <sup>11</sup>C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents

Chester A. Mathis, Yanming Wang, Daniel P. Holt et al. · Journal of Medicinal Chemistry · 2003 · 983 citations · Full text

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Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara et al. · Neuron · 2013 · 772 citations · Full text

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