Poria cocos polysaccharide attenuates RANKL-induced osteoclastogenesis by suppressing NFATc1 activity and phosphorylation of ERK and STAT3

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

David L. Lacey, Emma Timms, Hong‐Lin Tan et al. · Cell · 1998 · 5.4K citations · Full text

Inflammation, Osteoprotegerin Ligand, Sclerostin +13

The MAPK signaling cascade

Rony Seger, Edwin G. Krebs · The FASEB Journal · 1995 · 3.4K citations

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell · 2002 · 2.6K citations · Full text

Terminal Differentiation, Integrate Rankl Signaling, Developmental Biology +11

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

Sakae Tanaka, N. Takahashi, Nobuyuki Udagawa et al. · Journal of Clinical Investigation · 1993 · 575 citations · Full text

Regenerative Medicine, Developmental Biology, Final 2 +14

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Jian Luo, Zhengfeng Yang, Yu Ma et al. · Nature Medicine · 2016 · 356 citations

Developmental Biology, Bone Resorption, Bone Morphogenic Protein +11