N. Takahashi

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Nobuyuki Udagawa, N. Takahashi, Takuhiko Akatsu et al. · Proceedings of the National Academy of Sciences · 1990 · 1K citations

Medicine, Cell Biology, Immunology +14

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

T Tamura, Nobuyuki Udagawa, N. Takahashi et al. · Proceedings of the National Academy of Sciences · 1993 · 837 citations

Medicine, Immunology, Pathobiology +16

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

Sakae Tanaka, N. Takahashi, Nobuyuki Udagawa et al. · Journal of Clinical Investigation · 1993 · 577 citations · Full text

Medicine, Cell Biology, Immunology +13

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

Nobuyuki Udagawa, N. Takahashi, Takashi Katagiri et al. · The Journal of Experimental Medicine · 1995 · 419 citations · Full text

Life Sciences, Cell Biology, Immunology +11

Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor

Nobuyuki Udagawa, N. Takahashi, Eijiro Jimi et al. · Bone · 1999 · 414 citations

Medicine, Cell Biology, Oral Biology +15