Takuhiko Akatsu

IL-6 is produced by osteoblasts and induces bone resorption.

Yoshiko Ishimi, Chisato Miyaura, Cheng Jin et al. · The Journal of Immunology · 1990 · 1.1K citations

Medicine, Endocrinology, Immunology +14

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Nobuyuki Udagawa, N. Takahashi, Takuhiko Akatsu et al. · Proceedings of the National Academy of Sciences · 1990 · 1K citations

Medicine, Cell Biology, Immunology +14

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

Naoyuki Takahashi, Takuhiko Akatsu, Nobuyuki Udagawa et al. · Endocrinology · 1988 · 945 citations

Medicine, Cell Biology, Endocrinology +16

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

Sakae Tanaka, N. Takahashi, Nobuyuki Udagawa et al. · Journal of Clinical Investigation · 1993 · 577 citations · Full text

Medicine, Cell Biology, Immunology +13

The Bone Marrow-Derived Stromal Cell Lines MC3T3-G2/PA6 and ST2 Support Osteoclast-Like Cell Differentiation in Cocultures with Mouse Spleen Cells

Nobuyuki Udagawa, Naoyuki Takahashi, Takuhiko Akatsu et al. · Endocrinology · 1989 · 497 citations

Medicine, Cell Biology, Bone Metabolism +16