Concepedia

Nfatc1 Activation

NFATc1 Activation is a molecular signaling event characterized by the calcium-dependent dephosphorylation and nuclear translocation of the nuclear factor of activated T cells cytoplasmic 1 (NFATc1) transcription factor, which serves as a master regulator of osteoclast differentiation and gene expression during bone resorption.

867

Publications

54.5K

Citations

5K

Authors

1.2K

Institutions

Publications per year

2017–2026

297

Parents

Publications

867

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell · 2002 · 2.7K citations · Full text

, , +16

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

Masataka Asagiri, Kojiro Sato, Takako Usami et al. · The Journal of Experimental Medicine · 2005 · 848 citations · Full text

, , +15

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

Jugnu Jain, Zoe Miner, Tom K. Kerppola et al. · Nature · 1993 · 769 citations

, , +9

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Joseph R. Arron, Monte M. Winslow, Alberto Polleri et al. · Nature · 2006 · 698 citations

, , +11

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1

Antonio Musarò, Karl J. A. McCullagh, Francisco J. Naya et al. · Nature · 1999 · 647 citations

, , +7

1–5 of 867

Authors

5K

  1. JX
    Jiake Xu

    The University of Western Australia, Australia

    27 publications · 1.1K citations

    20

    h-index

  2. ES
    Edgar Serfling

    University of Würzburg, Germany

    18 publications · 2K citations

    17

    h-index

  3. AR
    Anjana Rao

    Harvard University, United States

    15 publications · 2.5K citations

    15

    h-index

  4. HK
    Hong‐Hee Kim

    Seoul National University, South Korea

    19 publications · 736 citations

    14

    h-index

  5. NK
    Nacksung Kim

    Chonnam National University, South Korea

    14 publications · 1.3K citations

    13

    h-index

1–5 of 5K

Institutions

1.2K

  1. Harvard University

    Cambridge, United States

    38 h-index

    156 publications

    25.5K citations

  2. The University of Western Australia

    Perth, Australia

    23 h-index

    170 publications

    7.3K citations

  3. University of Würzburg

    Würzburg, Germany

    20 h-index

    144 publications

    12.6K citations

  4. Yonsei University

    Seoul, South Korea

    18 h-index

    68 publications

    3.7K citations

  5. The University of Tokyo

    Tokyo, Japan

    18 h-index

    79 publications

    34.5K citations

  6. Shanghai Jiao Tong University

    Shanghai, China

    17 h-index

    133 publications

    8.2K citations

  7. Guangxi Medical University

    Nanning, China

    17 h-index

    79 publications

    2.2K citations

  8. Keio University

    Tokyo, Japan

    17 h-index

    76 publications

    9.2K citations

1–8 of 1.2K

Venues

  1. Journal of Biological Chemistry

    JBC · 66 publications · 6.4K citations

    43

    h-index

  2. The Journal of Immunology

    JI · 35 publications · 2.7K citations

    31

    h-index

  3. Journal of Bone and Mineral Research

    JBMR · 29 publications · 1.8K citations

    26

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.1K citations

    20

    h-index

  5. Journal of Cellular Physiology

    23 publications · 860 citations

    19

    h-index

1–5