Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

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Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

Gene M. Dubowchik, Raymond A. Firestone, Linda Padilla et al. · Bioconjugate Chemistry · 2002 · 546 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery:  Effects of Linker Technology on Efficacy and Toxicity

Svetlana O. Doronina, Brian A. Mendelsohn, Tim D. Bovee et al. · Bioconjugate Chemistry · 2005 · 512 citations

Pharmacy, Oncology, Pharmacology +17

Antibody-Drug Conjugates Designed to Eradicate Tumors with Homogeneous and Heterogeneous Expression of the Target Antigen

Yelena Kovtun, Charlene A. Audette, Yumei Ye et al. · Cancer Research · 2006 · 474 citations · Full text

Pharmacy, Oncology, Pharmacology +17

Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

S. Morris Kupchan, Yasuo Komoda, William A. Court et al. · Journal of the American Chemical Society · 1972 · 432 citations

Medicine, Medicinal Chemistry, Pharmacology +6