Thomas Markotan

7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa

Yu‐Kai Lee, Daniel J. Parks, Tianbao Lu et al. · Journal of Medicinal Chemistry · 2007 · 55 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Chemical Biology +16

Discovery and Clinical Evaluation of 1-{<i>N</i>-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

Tianbao Lu, Thomas Markotan, Shelley K. Ballentine et al. · Journal of Medicinal Chemistry · 2010 · 33 citations · Full text

Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis

Tianbao Lu, Thomas Markotan, Frank T. Coppo et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 25 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +11

A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists

Nalin L. Subasinghe, James C. Lanter, Thomas Markotan et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 21 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8

Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

Xuqing Zhang, Heather R. Hufnagel, Thomas Markotan et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 20 citations · Full text

Medicinal Chemistry, Heterocyclic, Biochemistry +11