Facile synthesis of 1,4-diketones<i>via</i>three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water

Abstract

Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way.