The role of 1,3-dithianes in natural product synthesis

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alfred W. Alberts, J Chen, G. W. Kuron et al. · Proceedings of the National Academy of Sciences · 1980 · 1.6K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Biochemistry, Pharmacology +10

Methods of Reactivity Umpolung

Dieter Seebàch · Angewandte Chemie International Edition in English · 1979 · 1.2K citations

Natural Sciences, Chemistry, Green Chemistry +9

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Akira Endo, Masao Kuroda, Yoshio Tsujita · The Journal of Antibiotics · 1976 · 954 citations · Full text

Life Sciences, Microbiology, Drug Discovery +2

Umpolung of the Reactivity of Carbonyl Compounds Through Sulfur-Containing Reagents

Bengt‐Thomas Gröbel, Dieter Seebàch · Synthesis · 1977 · 699 citations

Natural Sciences, Biochemistry, Chemistry +13