Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of dapagliflozin and saxagliptin in fixed-dose combination - Concepedia

Concepedia

Publication | Closed Access

Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of dapagliflozin and saxagliptin in fixed-dose combination

44

Citations

14

References

2018

Year

Narendra Singh, Parveen Bansal, M. Maithani, Yashpal Singh Chauhan

New Journal of Chemistry

Pharmaceutical SciencePharmacotherapySimultaneous EstimationFixed-dose CombinationMedicinal ChemistryBioanalysisAnalytical ChemistrySimultaneous DeterminationLiquid ChromatographyClinical ChemistryStability-indicating Rp-hplc MethodChromatographyTherapeutic Drug MonitoringBiochemistryPrecise StabilityChromatographic AnalysisPharmacologyNatural SciencesMedicinePharmacokineticsDrug DiscoveryDrug Analysis

Abstract

A simple and precise stability indicating method for the simultaneous estimation of dapagliflozin and saxagliptin in combined tablet dosage form was developed and validated using RP-HPLC.

References

	Year	Citations
Practical HPLC Method Development Analytical Chemistry EngineeringAltmetric Attention ScoreBibliometricsJournalismText Mining	1993	1.4K
Goodman and Gilman's The Pharmacological Basis of Therapeutics FRITZ T. FRAUNFELDER American Journal of Ophthalmology Medicinal ChemistryPharmacological StudyPharmacologyPharmacotherapyMedicine	1981	1.3K
Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes David J. Augeri, Jeffrey A. Robl, David A. Betebenner, Journal of Medicinal Chemistry	2005	617
Practical HPLC method development Lloyd R. Snyder, Joseph L. Glajch, Joseph J. Kirkland, Analytica Chimica Acta MedicineProcess Analytical TechnologyAnalytical ChemistryInstrumentationLaboratory Medicine	1991	245
Development and Validation of Stability Indicating RP-HPLC Method for Empagliflozin Sushil D. Patil, Sunil V. Amurutkar, Chandrashekhar D. Upasani Asian Journal of Pharmaceutical Analysis	2016	48
Development and Validation of UV Spectroscopic First Derivative Method for Simultaneous Estimation of Dapagliflozin and Metformin Hydrochloride in Synthetic Mixture Jani Br, Shah Kv, Kapupara Pp Journal of Bioequivalence Studies	2015	48
Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: Method validation and overcoming specific and non-specific binding at low concentrations Xiaohui Xu, Roger Demers, Huidong Gu, Journal of Chromatography B Method ValidationBiochemistryMedicineBioanalysisMass Spectrometry	2012	43
Development and validation of a reversed-phase column liquid chromatographic method for simultaneous determination of two novel gliptins in their binary mixtures with Metformin Mohammad Abdul‐Azim Mohammad, Ehab F. Elkady, Marwa A. Fouad European Journal of Chemistry Pharmaceutical ScienceEngineeringMetformin HclMedicinal ChemistryGas Chromatography	2012	37
Saxagliptin: the evidence for its place in the treatment of type 2 diabetes mellitus Steven V. Edelman Core evidence	2010	33
Spectrophotometric Methods Based on Charge Transfer ComplexationReactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation Bassam M. Ayoub, Ramzia I. El‐Bagary, Ehab F. Elkady International Journal of Biomedical Science ChemistrySpectrochemical AnalysisPharmacodynamic ModelingCharge Transfer ComplexesMedicinal Chemistry	2012	29

Page 1