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Spectrophotometric Methods Based on Charge Transfer ComplexationReactions for the Determination of Saxagliptin in Bulk and Pharmaceutical Preparation
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2012
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ChemistrySpectrochemical AnalysisPharmacodynamic ModelingCharge Transfer ComplexesMedicinal ChemistryGas ChromatographyDrug PurityBioanalysisAnalytical ChemistryLiquid ChromatographyClinical ChemistryChromatographySpectrophotometric MethodsPharmacokinetic ModelingBiochemistryPharmaceutical Dosage FormQuality ControlChromatographic AnalysisPharmacologyCharge Transfer ComplexationreactionsNatural SciencesMass SpectrometryMedicinePharmaceutical PreparationPharmacokineticsDrug Analysis
Simple, accurate and precise spectrophotometric methods have been developed for the determination of saxagliptin in bulk and dosage forms.The proposed methods are based on the charge transfer complexes of saxagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and7,7,8,8-tetracyanoquinodimethane (TCNQ). All the variables were studied to optimize the reactions' conditions. Beer's law was obeyed in the concentration ranges of 50-300 μg/ml and 10- 110 μg/ml with DDQ and TCNQ, respectively.The developed methods werevalidated and proved to be precise and accurate for the quality control of the saxagliptinin its pharmaceutical dosage form.