Development and Validation of UV Spectroscopic First Derivative Method for Simultaneous Estimation of Dapagliflozin and Metformin Hydrochloride in Synthetic Mixture

Abstract

The Novel, simple, sensitive, rapid, accurate and economical and reliable First derivative spectroscopic method has been developed for synthetic mixture of Dapagliflozin (DAPA) and Metformin hydrochloride (MET). This method involve solving of first derivative method based on measurement of absorbance at two wavelengths 235 nm and 272 nm using UV visible spectrophotometer with 1cm matched quartz cells and methanol solvent were employed in this method.