Bioinformatics · 2017 · 405 citations · 12 references
Life SciencesBioinformaticsMicrobiologyGenomicsMetagenomicsMicrobial SystematicsMetagenomic AnalysisMicrobial Community ProfilingTaxonomic ProfilingBacterial Taxonomic ProfilingBioinformatic PipelinesMicrobial Community CompositionMicrobial Community ModelingScientific FiguresTaxon Profiling
Summary: bioBakery is a meta'omic analysis environment and collection of individual software tools with the capacity to process raw shotgun sequencing data into actionable microbial community feature profiles, summary reports, and publication-ready figures. It includes a collection of pre-configured analysis modules also joined into workflows for reproducibility. Availability and implementation: bioBakery (http://huttenhower.sph.harvard.edu/biobakery) is publicly available for local installation as individual modules and as a virtual machine image. Each individual module has been developed to perform a particular task (e.g. quantitative taxonomic profiling or statistical analysis), and they are provided with source code, tutorials, demonstration data, and validation results; the bioBakery virtual image includes the entire suite of modules and their dependencies pre-installed. Images are available for both Amazon EC2 and Google Compute Engine. All software is open source under the MIT license. bioBakery is actively maintained with a support group at biobakery-users@googlegroups.com and new tools being added upon their release. Contact: chuttenh@hsph.harvard.edu. Supplementary information: Supplementary data are available at Bioinformatics online.
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Metagenomic biomarker discovery and explanation
Nicola Segata, Jacques Izard, Levi Waldron et al. · Genome biology · 2011 · 16.7K citations · Full text
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Xochitl C. Morgan, Timothy L. Tickle, Harry Sokol et al. · Genome biology · 2012 · 2.8K citations · Full text
Metagenomic microbial community profiling using unique clade-specific marker genes
Nicola Segata, Levi Waldron, Annalisa Ballarini et al. · Nature Methods · 2012 · 1.9K citations · Full text