Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 181.5K citations

Life Sciences, Molecular Biology, Molecular Genetics +9

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

Life Sciences, Cell Biology, Molecular Biology +12

The cytoprotective role of the Keap1–Nrf2 pathway

Liam Baird, Albena T. Dinkova‐Kostova · Archives of Toxicology · 2011 · 1K citations

Life Sciences, Biochemistry, Molecular Biology +13

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Ayako Enomoto · Toxicological Sciences · 2001 · 728 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · PubMed · 2001 · 656 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15