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Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Anthony B. Pinkerton, Eduard Sergienko, Yalda Bravo, Russell Dahl, Chen-Ting Ma, Qing Sun, Michael R. Jackson, Nicholas D. P. Cosford, José Luís Millán

Bioorganic & Medicinal Chemistry Letters · 2017 · 39 citations · 12 references

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12

<i>NT5E</i> Mutations and Arterial Calcifications

Cynthia St. Hilaire, Shira G. Ziegler, Thomas C. Markello et al. · New England Journal of Medicine · 2011 · 450 citations · Full text

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Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification

Koba A. Lomashvili, Puneet Garg, Sonoko Narisawa et al. · Kidney International · 2008 · 304 citations · Full text

, , +17

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

Ricardo Villa‐Bellosta, José Rivera, Fernando G. Osorio et al. · Circulation · 2013 · 211 citations · Full text

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Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification

Campbell R. Sheen, Pia Kuss, Sonoko Narisawa et al. · Journal of Bone and Mineral Research · 2014 · 190 citations · Full text

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Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

Shira G. Ziegler, Carlos R. Ferreira, Elena Gallo MacFarlane et al. · Science Translational Medicine · 2017 · 110 citations

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