Concepedia

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

Chen Cui, Ling Qing, L.S. Wang, Tianyi He, Fei Yan, F.Q. Liu, Ying H. Shen, Xinguo Hou, L. Chen

Metabolism · 2017 · 231 citations · 32 references

DOI

Concepts

References

32

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Isabelle Issemann, Stephen Green · Nature · 1990 · 3.5K citations

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.5K citations · Full text

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature · 2009 · 2.7K citations · Full text

, , +14

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

, , +12

STING is a direct innate immune sensor of cyclic di-GMP

Dara Burdette, Kathryn M. Monroe, Katia Troha et al. · Nature · 2011 · 1.5K citations

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