Concepedia

Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker

Anand Selvaraj, Hui-Ting Chen, Adela Ya-Ting Huang, Chai‐Lin Kao

Chemical Science · 2017 · 30 citations · 19 references

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Concepts

Abstract

through on-resin ligation in 77% yield in one day and a head-to-tail cyclic peptide, sunflower trypsin inhibitor-1, in 42% yield.

References

19

<b>Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide</b>

R. B. Merrifield · Journal of the American Chemical Society · 1963 · 7.6K citations

, , +6

An Efficient Fmoc‐SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

Juan B. Blanco‐Canosa, Philip E. Dawson · Angewandte Chemie International Edition · 2008 · 506 citations · Full text

, , +11

Protein chemical synthesis by serine and threonine ligation

Yinfeng Zhang, Ci Xu, Hiu Yung Lam et al. · Proceedings of the National Academy of Sciences · 2013 · 263 citations

, , +13

Chemical Protein Synthesis Using a Second-Generation <i>N</i>-Acylurea Linker for the Preparation of Peptide-Thioester Precursors

Juan B. Blanco‐Canosa, Brunello Nardone, Fernando Alberício et al. · Journal of the American Chemical Society · 2015 · 236 citations

, , +13

Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner's "Safety-Catch" Linker

Bradley J. Backes, Jonathan A. Ellman · Journal of the American Chemical Society · 1994 · 208 citations

, , +5