Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Abstract

Study on the chronic effects of an organophosphate chlorpyrifos inducing oxidative stress in freshwater culturable carp Ctenopharyngodon idellus has been made on exposure to sub lethal concentration micro g L and micro g L of the pesticide for and days Antioxidants viz catalase CAT superoxide dismutase SOD reduced glutathione GSH glutathione s transferase GST and lipid peroxidation LPO in the liver kidney and gills of the fish were analyzed Studies revealed that the enhanced productions of reactive oxygen species ROS lead to oxidative damage to lipids amp proteins and inhibit antioxidant defence system of fish The activity of LPO has followed an increasing trend and a decline in the activity of CAT SOD and GSH at both the concentrations throughout the experiment However no definite trend in the activity of GST has been observed Prolonged exposure to chlorpyrifos enhanced ROS formation finally resulted in oxidative damage to cell and inhibited antioxidant capacities in the fish tissues