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JAK1/2 Inhibitors AZD1480 and CYT387 Inhibit Canine B-Cell Lymphoma Growth by Increasing Apoptosis and Disrupting Cell Proliferation

Zhenzhen Lu, Courtney C. Hong, Paulo César Jark, Anna Luiza Facchetti Vinhaes Assumpção, Nathan Bollig, Guangyao Kong, Xuan Pan

Journal of Veterinary Internal Medicine · 2017 · 18 citations · 27 references

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Abstract

AZD1480 and CYT387 inhibit canine lymphoma cell growth in a dose-dependent manner. Our findings justify further phase I/II clinical investigations of the safety and efficacy of JAK1/2 inhibitors in canine DLBCL and suggest new opportunities for novel anticancer therapies.

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