Concepedia

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

Heidi J. Einolf, Wen Lin, Christina S. Won, Lai Wang, Helen Gu, Dung Yu Chun, Handan He, James B. Mangold

Drug Metabolism and Disposition · 2017 · 34 citations · 23 references

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References

23

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Ping Zhao, L Zhang, Joseph A. Grillo et al. · Clinical Pharmacology & Therapeutics · 2010 · 518 citations

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Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

, , +17

Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions

Ping Zhao, Malcolm Rowland, Huang Sm · Clinical Pharmacology & Therapeutics · 2012 · 211 citations · Full text

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Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

Eleanor J. Guest, Leon Aarons, J. Brian Houston et al. · Drug Metabolism and Disposition · 2010 · 191 citations

, , +15

The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review

S-M Huang, Malcolm Rowland · Clinical Pharmacology & Therapeutics · 2012 · 149 citations

, , +17