Concepedia

P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

Mahmoud G. Khalafalla, Lucas T. Woods, Jean M. Camden, Aslam Khan, Kirsten H. Limesand, Michael J. Petris, Laurie Erb, Gary A. Weisman

Journal of Biological Chemistry · 2017 · 82 citations · 60 references

DOIFull text

Open access

Concepts

Abstract

represents a promising therapeutic strategy to limit salivary gland inflammation and improve secretory function.

References

60

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

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Mitochondrial formation of reactive oxygen species

Julio F. Turrens · The Journal of Physiology · 2003 · 3.9K citations

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Catherine Dostert, Virginie Pétrilli, Robin van Bruggen et al. · Science · 2008 · 2.7K citations · Full text

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raúl Muñoz-Planillo, Peter Kuffa, Giovanny J. Martínez-Colón et al. · Immunity · 2013 · 2.1K citations

, , +16