Concepedia

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation <i>in vitro</i>

Nicholas A. DaSilva, Pragati Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H. Zawia, Angela L. Slitt, Navindra P. Seeram

Nutritional Neuroscience · 2017 · 89 citations · 29 references

DOIFull text

Open access

Abstract

The attenuation of neuroinflammation by urolithins may contribute, in part, toward pomegranate's neuroprotective effects against AD.

References

29

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Dongryeol Ryu, Laurent Mouchiroud, Pénélope A. Andreux et al. · Nature Medicine · 2016 · 981 citations · Full text

, , +10

Caspase signalling controls microglia activation and neurotoxicity

Miguel Ángel Burguillos, Tomas Deierborg, Edel Kavanagh et al. · Nature · 2011 · 586 citations · Full text

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Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

Juan Carlos Espı́n, Mar Larrosa, María‐Teresa García‐Conesa et al. · Evidence-based Complementary and Alternative Medicine · 2013 · 543 citations · Full text

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Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease

Richard E. Hartman, Aartie Shah, Anne M. Fagan et al. · Neurobiology of Disease · 2006 · 355 citations · Full text

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