Caspase signalling controls microglia activation and neurotoxicity

Miguel Ángel Burguillos, Tomas Deierborg, Edel Kavanagh, +8

Nature

InflammationMedicineImmunologyCell DeathBrain-immune Interaction +4

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

Miguel Ángel Burguillos, Martina Svensson, Tim Schulte, +17

Cell Reports

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

Xianli Shen, Miguel Ángel Burguillos, Ahmed M. Osman, +17

Nature Immunology

Neuro-oncologyMedicineImmunologyGlioma-induced InhibitionCell Death +8

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

Edel Kavanagh, Johanna Rodhe, Miguel Ángel Burguillos, +2

Cell Death and Disease

Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner

Katarzyna Mnich, Laura A. Carleton, Edel Kavanagh, +3

Cell Death and Disease

MitophagyApoptosisImmunologyPathologyCell Death +20

Nerve growth factor blocks thapsigargin‐induced apoptosis at the level of the mitochondrion <i>via</i>regulation of Bim

Éva Szegezdi, Kate Reed Herbert, Edel Kavanagh, +2

Journal of Cellular and Molecular Medicine

ApoptosisImmunologyCell DeathCell Death MechanismsCellular Physiology +17

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

Edel Kavanagh, Miguel Ángel Burguillos, Alejandro Carrillo-Jiménez, +5

Aging

Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine

Edel Kavanagh, John P. Loughlin, Kate Reed Herbert, +4

Biochemical and Biophysical Research Communications

MedicineNeuropharmacologyNeuroprotectionNgf-protected Pc12 CellsDopamine +2

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Bernardino Ossola, Ali Rifat, Anna Rowland, +28

Neuropharmacology

Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke

Johanna Rodhe, Miguel Ángel Burguillos, Rocío M. de Pablos, +6

Acta Neuropathologica Communications