Alcoholism Clinical and Experimental Research · 2017 · 16 citations · 31 references
Our results suggest that EtOH exposure can lead to pre-mRNA missplicing of Mcl-1 in neuronal cells. Our results indicate that EtOH exposure of neurons leads to a decrease in the ratio of Mcl-1L/Mcl-1S by favoring pro-apoptotic Mcl-1S splicing over anti-apoptotic Mcl-1L isoform suggesting that Mcl-1S may play a crucial role in neurotoxicity associated with alcohol consumption.
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Tomomi Kuwana, Lisa Bouchier‐Hayes, Jerry E. Chipuk et al. · Molecular Cell · 2005 · 1.2K citations · Full text
Molecular Physiology, Signal Transduction, Mitochondrial Function +9