Steviol stabilizes polycystin 1 expression and promotes lysosomal degradation of CFTR and β-catenin proteins in renal epithelial cells

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 790 citations · Full text

Renal Pathology, Renal Cystogenesis, Renal Inflammation +19

PKD1 Induces p21waf1 and Regulation of the Cell Cycle via Direct Activation of the JAK-STAT Signaling Pathway in a Process Requiring PKD2

Anil K. Bhunia, Klaus Piontek, Alessandra Boletta et al. · Cell · 2002 · 446 citations · Full text

Signal Transduction, Signaling Pathway, Cell Division +10

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

Katharina Hopp, Christopher J. Ward, Cynthia J. Hommerding et al. · Journal of Clinical Investigation · 2012 · 433 citations · Full text

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

Feng Qian, Alessandra Boletta, Anil K. Bhunia et al. · Proceedings of the National Academy of Sciences · 2002 · 325 citations · Full text

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

Sandro Rossetti, Vickie Kubly, Mark Consugar et al. · Kidney International · 2009 · 289 citations · Full text

Urology, Gene Dosage, Genetic Disorder +13