Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

Life Sciences, Cancer Biology, Molecular Biology +6

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Life Sciences, Cancer Biology, Molecular Biology +10

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

Isabelle Ray‐Coquard, Jean‐Yves Blay, Antoîne Italiano et al. · The Lancet Oncology · 2012 · 563 citations

Medicine, Cancer Biology, Oncology +16

Targeted rescue of a destabilized mutant of p53 by an <i>in silico</i> screened drug

Frank M. Boeckler, Andreas C. Joerger, Gaurav Jaggi et al. · Proceedings of the National Academy of Sciences · 2008 · 380 citations · Full text

Life Sciences, Molecular Biology, Oncology +17