The cell cycle regulator protein P16 and the cellular senescence of dental follicle cells

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

Telomere measurement by quantitative PCR

Richard Cawthon · Nucleic Acids Research · 2002 · 3.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text

Education, Cell Biology, Molecular Genetics +14

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq‐Chainiaux, Jorge D. Erusalimsky, Judith Campisi et al. · Nature Protocols · 2009 · 1.6K citations · Full text

Education, Cell Biology, Molecular Biology +11

Development and Validation of Real-Time Quantitative Reverse Transcriptase–Polymerase Chain Reaction for Monitoring Gene Expression in Cardiac Myocytesin Vitro

Jane Winer, Christopher Kwang S. Jung, Irene Shackel et al. · Analytical Biochemistry · 1999 · 1.4K citations

Life Sciences, Cell Biology, Molecular Biology +10