Concepedia

Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors

Mingfeng Shao, Linhong He, Li Zheng, Lingxiao Huang, Yuanyuan Zhou, Taijing Wang, Yong Chen, Mingsheng Shen, Fang Wang, Zhuang Yang,

Bioorganic & Medicinal Chemistry Letters · 2017 · 55 citations · 16 references

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16

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

, , +10

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

S. Picaud, Christopher Wells, I. Felletar et al. · Proceedings of the National Academy of Sciences · 2013 · 481 citations · Full text

, , +11

Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

Anup Dey, Akira Nishiyama, Tatiana Karpova et al. · Molecular Biology of the Cell · 2009 · 326 citations · Full text

, , +17

RVX-208

Dana Bailey, Ravi Jahagirdar, Allan Gordon et al. · Journal of the American College of Cardiology · 2010 · 229 citations